Frequently Asked Questions

Frequently Asked Questions

Is an aborted fetus used to source the stem cells?

No, our stem cells are sourced only from an umbilical cord that came from a live and healthy birth.

Do I need an inflammatory response for a good outcome?

No, it is not necessary. Responses occur without an explanation. However, pro-inflammatory responses will bring stronger anti-inflammatory responses.

What activity level can I have after receiving the injection?

Do not increase your activity level above your pre-injection activity level. Give the cells 3 weeks to aid in repair prior to starting an exercise program.

Do stem cells duplicate themselves in the body

No, stem cells do not duplicate themselves in the body. They do have the ability to duplicate themselves in vitro, in culture in the lab. They never duplicate themselves in the human body.

Do stem cells cause cancer or cause cancer to grow?

There are no direct large studies to show stem cells do not cause cancer. However, there are studies where stem cells are used to treat cancer. The conclusion is that since the cells effectively suppress cancer cells; it is then believed that they do not proliferate cancer cells nor cause formation of cancer cells.

Are live nucleated cells important?

Yes, the presence of live nucleated cells means that the anti inflammatory and immunomodulatory components from the cells will continue to be produced for many weeks and possibly months, re-molding and healing the injured environment.

Can I take stem cells with a biologic?

Since Biologics typically inhibit the immune system and stem cells activate and modulate the immune system, the use of Biologics could diminish the overall effect of the stem cells in the body.

Does an inflammatory response occur after receiving the stem cells?

Umbilical Cord Blood derived cells contain live nucleated cells and occasionally our body may have an immune response. It is not a graft vs. host response. It can be due to pro-inflammatory action of prostaglandin E-2. ( PGE2 can act as a pro-inflammatory agent or an anti-inflammatory agent), partially dependent on levels of IL-6 within the tissues.

How are the cells processed and are they safe?

According to the rules and regulations of the American Association of Tissue Banks ( AATB) the umbilical cord is processed in the hospital. The umbilical cords are donated from healthy mothers who’ve signed a consent and underwent a review of her medical history, social history and blood test . After the hospital process they are delivered to the lab for processing. Then they go to a 3rd party lab (CLIA) for sterility testing to detect bacteria/mold and fungus. After both lab reports come back “clean” and have passed the regulatory requirements, the processed umbilical cord stem cells are then available for distribution.

Do allogenic stem cells differentiate/change into new tissue in the body?

Research has shown that the vast majority of the function of the stem cells is for medicinal signaling and not differentiation. Stem cells produce long-term effects by responding to signals from injured tissues. The stem cells work by inhibiting the inflammatory components that cause pain and damage to tissue. The mononucleated cells secrete growth factors, proteins, and cytokines that stimulate our own tissue to repair and regenerate itself.

Are umbilical cord stem cells from another person (Allogeneic) safe to put into my body?

Yes, allogenic ( taken from another person of the same species) cells are safe to put into your body. When the umbilical cord is processed, all the red blood cell components that may cause a negative reaction are removed. Also, the umbilical cord cells are naive/immature and do not react the way a mature cell would.

“Mesenchymal stem cells produce huge quantities of bio-molecules, some of which are immunosuppressive; MSC’s put up a curtain molecule around themselves that allow donor(allogenic) MSC’s to be transplanted into a recipient, free from an immune response. (Immune privileged)”

Arnold Caplan, Ph.D. Case Western Reserve University.

Experimental and Molecular Medicine(2013) 45

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine.

Are umbilical cord cells the same as amniotic fluid

No, umbilical cord blood cells are live nucleated cells that contain stem cells that will continue to produce inflammatory and immunomodulatory components that optimize the local cellular environment. They also contain mononucleated cells that produce growth factors, proteins,

and cytokines that stimulate our own tissue to regenerate and heal itself. Because the cells are live they continue to exert these effects for weeks and even months.

How do umbilical cord stem cells actually work.

When umbilical cord cells are placed into an environment of injured tissue, the stem cells go to work by inhibiting the damaging inflammatory components and modulating the immune system. At the same time, the mononucleated cells produce growth factors that increase vasculature and nourish damaged cells back to health and stimulate our cells to regenerate themselves.

New England Neuroregenerative Center

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